BONE LOSS AS YOU AGE: MORIKAMI CALCIUM L-THREONATE

Bone Loss as You Age: Age-related bone loss involves a gradual and progressive decline, which is also seen in men. Markedly increased bone resorption leads to the initial fall in bone mineral density. With increasing age, there is also a significant reduction in bone formation. This is mostly due to a shift from osteoblast genesis to predominant adipogenesis in the bone marrow, which also has a lipotoxic effect that affects matrix formation and mineralization. New potential treatments are also considered, including therapeutic approaches to osteoporosis in the elderly that focus on the pathophysiology and potential reversal of adipogenicity shift in bone.

Calcium supplement best brand: CALCIUM L-THREONATE MORIKAMI

Bone Loss as You Age: Because of the aging process, the bone deteriorates in composition, structure and function, which predisposes to osteoporosis. Osteoporosis is defined as deterioration in bone mass and micro-architecture, with increasing risk to fragility fractures. Owing to the close relationship between the aging process of bone and the pathogenesis of osteoporosis, research on the mechanisms of age-related bone loss has increased significantly in recent years involving a combination of basic, clinical, observational and translational studies.

Calcium supplement best brand: CALCIUM L-THREONATE MORIKAMI

Bone Loss as You Age: Bone is a dynamic organ that serves mechanical and homeostatic functions. It undergoes a continual self-regeneration process called remodeling. Remodeling removes old bone and replaces it with new bone. This regenerative process occurs in distinct areas of bone known as bone metabolic units. With aging this balance shifts in a negative direction, favoring greater bone resorption and less bone formation. This combination of bone mass deficiency and reduction in strength ultimately results in osteoporosis and fractures.

Calcium supplement best brand: CALCIUM L-THREONATE MORIKAMI

Bone Loss as You Age: Aging in combination with intrinsic and extrinsic factors accelerates the decline in bone mass that predisposes to fractures. Intrinsic factors include genetics, peak bone mass accrual in youth, alterations in cellular components, hormonal, biochemical and vasculature status. Extrinsic factors include nutrition, physical activity, comorbid medical conditions and drugs. In addition, current and future therapeutic approaches focused on the correction of mechanisms associated with aging bone will also be outlined.